HIV Target gene Detail Information

> HIPK2 Gene Search Result

Gene Information

Gene Name	HIPK2
Gene ID	28996
Gene Full Name	homeodomain interacting protein kinase 2
Gene Alias	PRO0593
Transcripts	ENSG00000064393
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q9H2X6
HGNC ID	HGNC:14402
VEGA ID	OTTHUMG00000157704
OMIM ID	606868
String ID	9606.ENSP00000385571
Drugbank ID	BE0009401
PharmGKB ID	PA29291

Target gene [HIPK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002442	chr7	24	44	26	94	View
4004077	chr7	19	31		50	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HIPK2 expression and immune infiltrating cell level correlation result in HIV+ samples
HIPK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HIPK2 expression and immune infiltrating cell level correlation result in HIV+ samples
HIPK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).