HBV Target gene Detail Information

> HIF1A Gene Search Result

Gene Information

Gene Name	HIF1A
Gene ID	3091
Gene Full Name	hypoxia inducible factor 1 subunit alpha
Gene Alias	HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha
Transcripts	ENSG00000100644
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nuclear bodies;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q16665
HGNC ID	HGNC:4910
VEGA ID	OTTHUMG00000140344
OMIM ID	603348
String ID	9606.ENSP00000437955
Drugbank ID	BE0002374
PharmGKB ID	PA29283

Target gene [HIF1A] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Detail
1	24346287	K130M	X	View
2	24346287	V131I	X	View
3	25019072	K130M	X	View
4	32887289	M204I	RT	View
5	32887289	W196*	S	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of HIF1A expression and immune infiltrating cell level correlation result in HBV+ samples
HIF1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: LIHC