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HBV Target gene Detail Information

> HIBADH Gene Search Result


Gene Information
Gene Name HIBADH
Gene ID 11112
Gene Full Name 3-hydroxyisobutyrate dehydrogenase
Gene Alias NS5ATP1
Transcripts ENSG00000106049
Virus HBV
Gene Type protein coding
HPA Location Info
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID P31937
HGNC ID HGNC:4907
VEGA ID OTTHUMG00000097035
OMIM ID 608475
String ID 9606.ENSP00000265395
Drugbank ID BE0000128
PharmGKB ID PA29280
Target gene [HIBADH] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001435 chr7 106 458 147 711 View
1003782 chr7 26 21 65 112 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of HIBADH expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HIBADH expression: Low -> High
Lollipop of HIBADH expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of HIBADH expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HIBADH expression and immune infiltrating cell level correlation result in HBV+ samples
HIBADH expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).