HPV Target gene Detail Information

> HGD Gene Search Result

Gene Information

Gene Name	HGD
Gene ID	3081
Gene Full Name	homogentisate 1,2-dioxygenase
Gene Alias	AKU; HGO
Transcripts	ENSG00000113924
Virus	HPV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q93099
HGNC ID	HGNC:4892
VEGA ID	OTTHUMG00000159441
OMIM ID	607474
String ID	9606.ENSP00000283871
PharmGKB ID	PA29268

Target gene [HGD] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5201656	chr3	5	3		8	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of HGD expression and immune infiltrating cell level correlation result in HPV+ samples
HGD expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662