HIV Target gene Detail Information

> HERC4 Gene Search Result

Gene Information

Gene Name	HERC4
Gene ID	26091
Gene Full Name	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Transcripts	ENSG00000148634
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoli fibrillar center;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q5GLZ8
HGNC ID	HGNC:24521
VEGA ID	OTTHUMG00000018343
OMIM ID	609248
String ID	9606.ENSP00000378624
PharmGKB ID	PA134949021

Target gene [HERC4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013277	chr10	2	2		4	View
4013557	chr10	2	1		3	View
4013966	chr10	1	2		3	View
4015776	chr10		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HERC4 expression and immune infiltrating cell level correlation result in HIV+ samples
HERC4 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HERC4 expression and immune infiltrating cell level correlation result in HIV+ samples
HERC4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).