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HIV Target gene Detail Information

> HERC4 Gene Search Result


Gene Information
Gene Name HERC4
Gene ID 26091
Gene Full Name HECT and RLD domain containing E3 ubiquitin protein ligase 4
Transcripts ENSG00000148634
Virus HIV
Gene Type protein coding
HPA Location Info Cytosol;Nucleoli fibrillar center;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID Q5GLZ8
HGNC ID HGNC:24521
VEGA ID OTTHUMG00000018343
OMIM ID 609248
String ID 9606.ENSP00000378624
PharmGKB ID PA134949021
Target gene [HERC4] related to VISs
DVIDChromosomeHMTFBSCASum of Overlapped RecordsDetail
4013277 chr10 2 2 4 View
4013557 chr10 2 1 3 View
4013966 chr10 1 2 3 View
4015776 chr10 1 1 View
Showing 1 to 4 of 4 entries
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Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of HERC4 expression and immune infiltrating cell level correlation result in HIV+ samples
HERC4 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of HERC4 expression and immune infiltrating cell level correlation result in HIV+ samples
HERC4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).