HIV Target gene Detail Information

> HERC3 Gene Search Result

Gene Information

Gene Name	HERC3
Gene ID	8916
Gene Full Name	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Transcripts	ENSG00000287542
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Enzymes, Predicted intracellular proteins
Uniport_ID	Q15034
HGNC ID	HGNC:4876
VEGA ID	OTTHUMG00000150436
OMIM ID	605200
String ID	9606.ENSP00000385684
PharmGKB ID	PA29251

Target gene [HERC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004497	chr4	25	18		43	View
4015121	chr4	1			1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HERC3 expression and immune infiltrating cell level correlation result in HIV+ samples
HERC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).