HIV Target gene Detail Information

> HEMK1 Gene Search Result

Gene Information

Gene Name	HEMK1
Gene ID	51409
Gene Full Name	HemK methyltransferase family member 1
Gene Alias	HEMK; MTQ1
Transcripts	ENSG00000114735
Virus	HIV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9Y5R4
HGNC ID	HGNC:24923
VEGA ID	OTTHUMG00000156849
OMIM ID	618609
String ID	9606.ENSP00000404843
PharmGKB ID	PA134884011

Target gene [HEMK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001783	chr3	10	47	75	132	View
4008267	chr3	16			16	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HEMK1 expression and immune infiltrating cell level correlation result in HIV+ samples
HEMK1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HEMK1 expression and immune infiltrating cell level correlation result in HIV+ samples
HEMK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).