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HBV Target gene Detail Information

> HELZ Gene Search Result


Gene Information
Gene Name HELZ
Gene ID 9931
Gene Full Name helicase with zinc finger
Gene Alias DHRC; DRHC; HUMORF5
Transcripts ENSG00000198265
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli;Nucleoli rim;Actin filaments;Plasma membrane;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P42694
HGNC ID HGNC:16878
VEGA ID OTTHUMG00000179555
OMIM ID 606699
String ID 9606.ENSP00000351524
PharmGKB ID PA29238
Target gene [HELZ] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003615 chr17 14 43 64 121 View
1402063 chr17 14 43 64 121 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of HELZ expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HELZ expression: Low -> High
Lollipop of HELZ expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of HELZ expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HELZ expression and immune infiltrating cell level correlation result in HBV+ samples
HELZ expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).