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HBV Target gene Detail Information

> HDAC9 Gene Search Result


Gene Information
Gene Name HDAC9
Gene ID 9734
Gene Full Name histone deacetylase 9
Gene Alias HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
Transcripts ENSG00000048052
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID Q9UKV0
HGNC ID HGNC:14065
VEGA ID OTTHUMG00000152487
OMIM ID 606543
String ID 9606.ENSP00000408617
Drugbank ID BE0000881; BE0008667
Drug (Cytoscape Annotation) Vorinostat;Panobinostat;Belinostat
PharmGKB ID PA38377
FDA Approved Drug Romidepsin;Belinostat;Panobinostat;Vorinostat
Target gene [HDAC9] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007782 chr7 12 6 6 24 View
1008395 chr7 18 3 21 View
1010853 chr7 10 1 11 View
1011588 chr7 6 2 8 View
1015377 chr7 2 2 View
1019760 chr7 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of HDAC9 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HDAC9 expression: Low -> High
Lollipop of HDAC9 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of HDAC9 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HDAC9 expression and immune infiltrating cell level correlation result in HBV+ samples
HDAC9 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).