Home
Virus
Gene
Disease
Dataset
Download
Help
 
HBV Target gene Detail Information

> HDAC4 Gene Search Result


Gene Information
Gene Name HDAC4
Gene ID 9759
Gene Full Name histone deacetylase 4
Gene Alias HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
Transcripts ENSG00000068024
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Cytosol;Nucleoplasm;
HPA Protein Class Info Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins
Uniport_ID P56524
HGNC ID HGNC:14063
VEGA ID OTTHUMG00000133344
OMIM ID 605314
String ID 9606.ENSP00000264606
Drugbank ID BE0003523; BE0008667
Drug (Cytoscape Annotation) Panobinostat;Vorinostat;Romidepsin;Belinostat
PharmGKB ID PA29229
Target gene [HDAC4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1007542 chr2 24 2 26 View
1400462 chr2 12 14 26 View
1400463 chr2 12 12 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of HDAC4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HDAC4 expression: Low -> High
Lollipop of HDAC4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of HDAC4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HDAC4 expression and immune infiltrating cell level correlation result in HBV+ samples
HDAC4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).