HBV Target gene Detail Information

> HDAC3 Gene Search Result

Gene Information

Gene Name	HDAC3
Gene ID	8841
Gene Full Name	histone deacetylase 3
Gene Alias	HD3; RPD3; RPD3-2
Transcripts	ENSG00000171720
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Golgi apparatus;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	O15379
HGNC ID	HGNC:4854
VEGA ID	OTTHUMG00000129629
OMIM ID	605166
String ID	9606.ENSP00000302967
Drugbank ID	BE0002367; BE0008667
Drug (Cytoscape Annotation)	Romidepsin;Panobinostat;Vorinostat;Belinostat
PharmGKB ID	PA29228

Target gene [HDAC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1400647	chr5	11	3	1	15	View
1400648	chr5	15	9		24	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of HDAC3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HDAC3 expression: Low -> High
Lollipop of HDAC3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of HDAC3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of HDAC3 expression and immune infiltrating cell level correlation result in HBV+ samples
HDAC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).