HIV Target gene Detail Information

> HBS1L Gene Search Result

Gene Information

Gene Name	HBS1L
Gene ID	10767
Gene Full Name	HBS1 like translational GTPase
Gene Alias	ERFS; HBS1; EF-1a; eRF3c; HSPC276
Transcripts	ENSG00000112339
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nuclear bodies;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q9Y450
HGNC ID	HGNC:4834
VEGA ID	OTTHUMG00000015626
OMIM ID	612450
String ID	9606.ENSP00000356811
PharmGKB ID	PA29209

Target gene [HBS1L] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000120	chr6	276	498	218	992	View
4000375	chr6	297	113	98	508	View
4001311	chr6	178	2		180	View
4010225	chr6	5	4		9	View
4013219	chr6	1	3		4	View
4013727	chr6	3			3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HBS1L expression and immune infiltrating cell level correlation result in HIV+ samples
HBS1L expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HBS1L expression and immune infiltrating cell level correlation result in HIV+ samples
HBS1L expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).