HIV Target gene Detail Information

> HADHB Gene Search Result

Gene Information

Gene Name	HADHB
Gene ID	3032
Gene Full Name	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Gene Alias	ECHB; MTPB; MSTP029; TP-BETA
Transcripts	ENSG00000138029
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P55084
HGNC ID	HGNC:4803
VEGA ID	OTTHUMG00000096978
OMIM ID	143450
String ID	9606.ENSP00000325136
PharmGKB ID	PA29177
FDA Approved Drug	Triheptanoin

Target gene [HADHB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4008694	chr2	12		2	14	View
4008857	chr2	4	8	1	13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HADHB expression and immune infiltrating cell level correlation result in HIV+ samples
HADHB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HADHB expression and immune infiltrating cell level correlation result in HIV+ samples
HADHB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).