HTLV1 Target gene Detail Information

> GUCA1A Gene Search Result

Gene Information

Gene Name	GUCA1A
Gene ID	2978
Gene Full Name	guanylate cyclase activator 1A
Gene Alias	COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
Transcripts	ENSG00000048545
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	P43080
HGNC ID	HGNC:4678
VEGA ID	OTTHUMG00000014696
OMIM ID	600364
String ID	9606.ENSP00000377784
Drugbank ID	BE0004244
PharmGKB ID	PA29062

Target gene [GUCA1A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6016050	chr6	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GUCA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GUCA1A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GUCA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GUCA1A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GUCA1A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GUCA1A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).