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HBV Target gene Detail Information

> GSK3B Gene Search Result


Gene Information
Gene Name GSK3B
Gene ID 2932
Gene Full Name glycogen synthase kinase 3 beta
Transcripts ENSG00000082701
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Gene Function Suppressor gene
Uniport_ID P49841
HGNC ID HGNC:4617
VEGA ID OTTHUMG00000133765
OMIM ID 605004
String ID 9606.ENSP00000324806
Drugbank ID BE0001065
PharmGKB ID PA29009
Target gene [GSK3B] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 17622616 P101S
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Target gene [GSK3B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003132 chr3 104 28 31 163 View
1403659 chr3 104 28 31 163 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of GSK3B expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
GSK3B expression: Low -> High
Lollipop of GSK3B expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of GSK3B expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of GSK3B expression and immune infiltrating cell level correlation result in HBV+ samples
GSK3B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).