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HBV Target gene Detail Information

> GRK5 Gene Search Result


Gene Information
Gene Name GRK5
Gene ID 2869
Gene Full Name G protein-coupled receptor kinase 5
Gene Alias GPRK5; FP2025
Transcripts ENSG00000198873
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear membrane;Nuclear speckles;Plasma membrane;
HPA Protein Class Info Enzymes, Predicted intracellular proteins
Uniport_ID P34947
HGNC ID HGNC:4544
VEGA ID OTTHUMG00000019149
OMIM ID 600870
String ID 9606.ENSP00000376609
PharmGKB ID PA180
Target gene [GRK5] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001814 chr10 300 174 1 475 View
1002019 chr10 229 146 375 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of GRK5 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
GRK5 expression: Low -> High
Lollipop of GRK5 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of GRK5 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of GRK5 expression and immune infiltrating cell level correlation result in HBV+ samples
GRK5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).