HTLV1 Target gene Detail Information

> GRIK5 Gene Search Result

Gene Information

Gene Name	GRIK5
Gene ID	2901
Gene Full Name	glutamate ionotropic receptor kainate type subunit 5
Gene Alias	KA2; EAA2; GRIK2; GluK5
Transcripts	ENSG00000105737
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins
Uniport_ID	Q16478
HGNC ID	HGNC:4583
VEGA ID	OTTHUMG00000044573
OMIM ID	600283
String ID	9606.ENSP00000262895
Drugbank ID	BE0000828; BE0009793
PharmGKB ID	PA28977

Target gene [GRIK5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003234	chr19	115	49	9	173	View
6006749	chr19	51	12	1	64	View
6006917	chr19	49	12	1	62	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GRIK5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRIK5 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GRIK5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRIK5 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GRIK5 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRIK5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).