HTLV1 Target gene Detail Information

> GRHL3 Gene Search Result

Gene Information

Gene Name	GRHL3
Gene ID	57822
Gene Full Name	grainyhead like transcription factor 3
Gene Alias	SOM; VWS2; TFCP2L4
Transcripts	ENSG00000158055
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Uniport_ID	Q8TE85
HGNC ID	HGNC:25839
VEGA ID	OTTHUMG00000003040
OMIM ID	608317
String ID	9606.ENSP00000288955
PharmGKB ID	PA134987320

Target gene [GRHL3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001661	chr1	292	46	35	373	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GRHL3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRHL3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GRHL3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRHL3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GRHL3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GRHL3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).