HTLV1 Target gene Detail Information

> GREM1 Gene Search Result

Gene Information

Gene Name	GREM1
Gene ID	26585
Gene Full Name	gremlin 1, DAN family BMP antagonist
Gene Alias	DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
Transcripts	ENSG00000276886
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Predicted secreted proteins
Gene Function	Suppressor gene & Oncogene
Uniport_ID	O60565
HGNC ID	HGNC:2001
VEGA ID	OTTHUMG00000129319
OMIM ID	603054
String ID	9606.ENSP00000478319
PharmGKB ID	PA26537

Target gene [GREM1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6004967	chr15	2	97	1	100	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GREM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GREM1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GREM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GREM1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GREM1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GREM1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).