HIV Target gene Detail Information

> GRB2 Gene Search Result

Gene Information

Gene Name	GRB2
Gene ID	2885
Gene Full Name	growth factor receptor bound protein 2
Gene Alias	ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
Transcripts	ENSG00000177885
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Nucleoli;
HPA Protein Class Info	Cancer-related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	P62993
HGNC ID	HGNC:4566
VEGA ID	OTTHUMG00000134332
OMIM ID	108355
String ID	9606.ENSP00000376345
Drugbank ID	BE0000917
PharmGKB ID	PA28962

Target gene [GRB2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000412	chr17	82	282	120	484	View
4000480	chr17	89	262	83	434	View
4002543	chr17	89		1	90	View
4002871	chr17	73	3	1	77	View
4003422	chr17	61	1		62	View
4003669	chr17	35	16	5	56	View
4003679	chr17	55	1		56	View
4005883	chr17	20	9		29	View
4006030	chr17	13	14		27	View
4006337	chr17	24	1		25	View
4006567	chr17	6	6	12	24	View
4007751	chr17	4	14		18	View
4008945	chr17	1	8	4	13	View
4009937	chr17	7	3		10	View
4012922	chr17	3	1		4	View
4014165	chr17	2			2	View
4014166	chr17	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of GRB2 expression and immune infiltrating cell level correlation result in HIV+ samples
GRB2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of GRB2 expression and immune infiltrating cell level correlation result in HIV+ samples
GRB2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).