HIV Target gene Detail Information

> GRAP2 Gene Search Result

Gene Information

Gene Name	GRAP2
Gene ID	9402
Gene Full Name	GRB2 related adaptor protein 2
Gene Alias	P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2
Transcripts	ENSG00000100351
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	O75791
HGNC ID	HGNC:4563
VEGA ID	OTTHUMG00000151097
OMIM ID	604518
String ID	9606.ENSP00000339186
PharmGKB ID	PA28959

Target gene [GRAP2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002317	chr22	83	17		100	View
4002972	chr22	5	66	2	73	View
4006889	chr22	22			22	View
4007857	chr22	7	10		17	View
4009344	chr22	3	7	2	12	View
4009503	chr22	10	1		11	View
4010425	chr22	9			9	View
4011746	chr22	6			6	View
4012755	chr22	4			4	View
4014208	chr22	2			2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of GRAP2 expression and immune infiltrating cell level correlation result in HIV+ samples
GRAP2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of GRAP2 expression and immune infiltrating cell level correlation result in HIV+ samples
GRAP2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).