HBV Target gene Detail Information

> GPT Gene Search Result

Gene Information

Gene Name	GPT
Gene ID	2875
Gene Full Name	glutamic--pyruvic transaminase
Gene Alias	AAT1; ALT1; GPT1
Transcripts	ENSG00000167701
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P24298
HGNC ID	HGNC:4552
VEGA ID	OTTHUMG00000165176
OMIM ID	138200
String ID	9606.ENSP00000378408
Drugbank ID	BE0000667; BE0002009
PharmGKB ID	PA28947

Target gene [GPT] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	18171343	F134L	S	D G S C	View
2	18171343	T555C	S	D G S C	View
3	27446286	M204V	RT	D G R C	View
4	29285238	F132R	X	G R S C	View
5	30835025	T1753V	BCP	G R C	View
6	12853747	L180M	RT	D I	View
7	15544736	L180M	RT	D C	View
8	15720534	A1762T	BCP	G	View
9	27998820	P79Q	C	G C	View
10	12010505	A1762T	BCP	C	View
11	12010505	G1764A	BCP	C	View
12	12010505	G1896A	PreC	C	View
13	12010505	T1753C	BCP	C	View
14	12368144	L256M	RT	D	View
15	12931030	A1762T	BCP	D	View
16	15720530	L180M	RT	D	View
17	29479565	A2189C	C	C	View
18	29479565	G1764A	BCP	C	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of GPT expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
GPT expression: Low -> High
Lollipop of GPT expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of GPT expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of GPT expression and immune infiltrating cell level correlation result in HBV+ samples
GPT expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).