HTLV1 Target gene Detail Information

> GPR68 Gene Search Result

Gene Information

Gene Name	GPR68
Gene ID	8111
Gene Full Name	G protein-coupled receptor 68
Gene Alias	OGR1; AI2A6; GPR12A
Transcripts	ENSG00000119714
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins
Uniport_ID	Q15743
HGNC ID	HGNC:4519
VEGA ID	OTTHUMG00000167590
OMIM ID	601404
String ID	9606.ENSP00000434045
PharmGKB ID	PA28911

Target gene [GPR68] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000684	chr14	341	184	459	984	View
6008831	chr14	9	6	27	42	View
6027858	chr14		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GPR68 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GPR68 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GPR68 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GPR68 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GPR68 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GPR68 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).