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HPV Target gene Detail Information

> GPR6 Gene Search Result


Gene Information
Gene Name GPR6
Gene ID 2830
Gene Full Name G protein-coupled receptor 6
Transcripts ENSG00000146360
Virus HPV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info G-protein coupled receptors, Predicted membrane proteins
Uniport_ID P46095
HGNC ID HGNC:4515
VEGA ID OTTHUMG00000015354
OMIM ID 600553
String ID 9606.ENSP00000406986
PharmGKB ID PA28904
Target gene [GPR6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5200982 chr6 43 1 1 45 View
5404211 chr6 25 5 30 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE140662 (GEO) Condyloma Acuminatum 8 Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of GPR6 expression and immune infiltrating cell level correlation result in HPV+ samples
GPR6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).