HBV Target gene Detail Information

> GOT1 Gene Search Result

Gene Information

Gene Name	GOT1
Gene ID	2805
Gene Full Name	glutamic-oxaloacetic transaminase 1
Gene Alias	AST1; cCAT; GIG18; cAspAT; ASTQTL1
Transcripts	ENSG00000120053
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P17174
HGNC ID	HGNC:4432
VEGA ID	OTTHUMG00000018882
OMIM ID	138180
String ID	9606.ENSP00000359539
Drugbank ID	BE0000529
PharmGKB ID	PA28817

Target gene [GOT1] related to virus gene/protein/region

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	22930502	M204I	RT	D G C	View
2	27651827	K13E	PreS1	G S C	View
3	27920641	G1896A	PreC	G	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of GOT1 expression and immune infiltrating cell level correlation result in HBV+ samples
GOT1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: LIHC