HTLV1 Target gene Detail Information

> GNB4 Gene Search Result

Gene Information

Gene Name	GNB4
Gene ID	59345
Gene Full Name	G protein subunit beta 4
Gene Alias	CMTD1F
Transcripts	ENSG00000114450
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Plasma membrane;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, RAS pathway related proteins
Uniport_ID	Q9HAV0
HGNC ID	HGNC:20731
VEGA ID	OTTHUMG00000157440
OMIM ID	610863
String ID	9606.ENSP00000232564
PharmGKB ID	PA134864200

Target gene [GNB4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6005290	chr3	17	64	10	91	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GNB4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GNB4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GNB4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GNB4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GNB4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GNB4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).