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HIV Target gene Detail Information

> GNB1 Gene Search Result


Gene Information
Gene Name GNB1
Gene ID 2782
Gene Full Name G protein subunit beta 1
Gene Alias MRD42
Transcripts ENSG00000078369
Virus HIV
Gene Type protein coding
HPA Location Info Plasma membrane;Golgi apparatus;
HPA Protein Class Info Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters
Uniport_ID P62873
HGNC ID HGNC:4396
VEGA ID OTTHUMG00000000940
OMIM ID 139380
String ID 9606.ENSP00000481878
PharmGKB ID PA28776
Target gene [GNB1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000709 chr1 291 16 2 309 View
4000946 chr1 9 215 17 241 View
4001010 chr1 115 81 33 229 View
4001339 chr1 170 6 176 View
4001540 chr1 123 13 17 153 View
4001705 chr1 127 9 2 138 View
4002744 chr1 63 1 17 81 View
4002933 chr1 73 2 75 View
4003706 chr1 30 11 15 56 View
4004636 chr1 34 7 41 View
4004858 chr1 36 2 38 View
4005126 chr1 20 15 35 View
4006211 chr1 19 7 26 View
4006212 chr1 9 14 3 26 View
4007226 chr1 20 20 View
4007289 chr1 8 9 3 20 View
4007388 chr1 18 1 19 View
4008376 chr1 14 1 15 View
4009356 chr1 10 2 12 View
4009429 chr1 9 2 11 View
4011302 chr1 7 7 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of GNB1 expression and immune infiltrating cell level correlation result in HIV+ samples
GNB1 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of GNB1 expression and immune infiltrating cell level correlation result in HIV+ samples
GNB1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).