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HBV Target gene Detail Information

> GGT1 Gene Search Result


Gene Information
Gene Name GGT1
Gene ID 2678
Gene Full Name gamma-glutamyltransferase 1
Gene Alias GGT; GTG; GGTD; CD224; GGT 1; D22S672; D22S732
Transcripts ENSG00000100031
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P19440
HGNC ID HGNC:4250
VEGA ID OTTHUMG00000030859
OMIM ID 612346
String ID 9606.ENSP00000383232
Drugbank ID BE0000889
PharmGKB ID PA28662
Target gene [GGT1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1017742 chr22 0 View
1403108 chr22 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of GGT1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
GGT1 expression: Low -> High
Lollipop of GGT1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of GGT1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of GGT1 expression and immune infiltrating cell level correlation result in HBV+ samples
GGT1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).