HIV Target gene Detail Information

> GEN1 Gene Search Result

Gene Information

Gene Name	GEN1
Gene ID	348654
Gene Full Name	GEN1, Holliday junction 5' flap endonuclease
Gene Alias	Gen
Transcripts	ENSG00000178295
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q17RS7
HGNC ID	HGNC:26881
VEGA ID	OTTHUMG00000121173
OMIM ID	612449
String ID	9606.ENSP00000318977
PharmGKB ID	PA162389359

Target gene [GEN1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4010307	chr2	7	2		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of GEN1 expression and immune infiltrating cell level correlation result in HIV+ samples
GEN1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of GEN1 expression and immune infiltrating cell level correlation result in HIV+ samples
GEN1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).