HTLV1 Target gene Detail Information

> GDNF Gene Search Result

Gene Information

Gene Name	GDNF
Gene ID	2668
Gene Full Name	glial cell derived neurotrophic factor
Gene Alias	ATF; ATF1; ATF2; HSCR3; HFB1-GDNF
Transcripts	ENSG00000168621
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P39905
HGNC ID	HGNC:4232
VEGA ID	OTTHUMG00000090809
OMIM ID	600837
String ID	9606.ENSP00000409007
Drugbank ID	BE0002486
PharmGKB ID	PA28644

Target gene [GDNF] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003374	chr5	129	25	10	164	View
6023417	chr5	2	1	1	4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GDNF expression and immune infiltrating cell level correlation result in HTLV1+ samples
GDNF expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GDNF expression and immune infiltrating cell level correlation result in HTLV1+ samples
GDNF expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GDNF expression and immune infiltrating cell level correlation result in HTLV1+ samples
GDNF expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).