HTLV1 Target gene Detail Information

> GCH1 Gene Search Result

Gene Information

Gene Name	GCH1
Gene ID	2643
Gene Full Name	GTP cyclohydrolase 1
Gene Alias	GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
Transcripts	ENSG00000131979
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nuclear membrane;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P30793
HGNC ID	HGNC:4193
VEGA ID	OTTHUMG00000029754
OMIM ID	600225
String ID	9606.ENSP00000419045
Drugbank ID	BE0001055
PharmGKB ID	PA28608

Target gene [GCH1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000193	chr14	2928	173	47	3148	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GCH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GCH1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GCH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GCH1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GCH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GCH1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).