HTLV1 Target gene Detail Information

> GATA4 Gene Search Result

Gene Information

Gene Name	GATA4
Gene ID	2626
Gene Full Name	GATA binding protein 4
Gene Alias	TOF; ASD2; VSD1; TACHD
Transcripts	ENSG00000285109
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nuclear bodies;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	P43694
HGNC ID	HGNC:4173
VEGA ID	OTTHUMG00000090800
OMIM ID	600576
String ID	9606.ENSP00000334458
PharmGKB ID	PA28587

Target gene [GATA4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002877	chr8	119	57	26	202	View
6012270	chr8	19	4		23	View
6015347	chr8	12	2		14	View
6018489	chr8	8	1		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).