HTLV1 Target gene Detail Information

> GATA4 Gene Search Result


Gene Information
Gene Name GATA4
Gene ID 2626
Gene Full Name GATA binding protein 4
Gene Alias TOF; ASD2; VSD1; TACHD
Transcripts ENSG00000285109
Virus HTLV1
Gene Type protein coding
HPA Location Info Nuclear bodies;
HPA Protein Class Info Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene
Uniport_ID P43694
HGNC ID HGNC:4173
VEGA ID OTTHUMG00000090800
OMIM ID 600576
String ID 9606.ENSP00000334458
PharmGKB ID PA28587
Target gene [GATA4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002877 chr8 119 57 26 202 View
6012270 chr8 19 4 23 View
6015347 chr8 12 2 14 View
6018489 chr8 8 1 9 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of GATA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GATA4 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).