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HTLV1 Target gene Detail Information

> GALC Gene Search Result


Gene Information
Gene Name GALC
Gene ID 2581
Gene Full Name galactosylceramidase
Transcripts ENSG00000054983
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P54803
HGNC ID HGNC:4115
VEGA ID OTTHUMG00000028646
OMIM ID 606890
String ID 9606.ENSP00000261304
PharmGKB ID PA28530
Target gene [GALC] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6009951 chr14 4 28 2 34 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of GALC expression and immune infiltrating cell level correlation result in HTLV1+ samples
GALC expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of GALC expression and immune infiltrating cell level correlation result in HTLV1+ samples
GALC expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of GALC expression and immune infiltrating cell level correlation result in HTLV1+ samples
GALC expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).