HTLV1 Target gene Detail Information

> GADD45A Gene Search Result

Gene Information

Gene Name	GADD45A
Gene ID	1647
Gene Full Name	growth arrest and DNA damage inducible alpha
Gene Alias	DDIT1; GADD45
Transcripts	ENSG00000116717
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nuclear speckles;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P24522
HGNC ID	HGNC:4095
VEGA ID	OTTHUMG00000009374
OMIM ID	126335
String ID	9606.ENSP00000360025
PharmGKB ID	PA28510

Target gene [GADD45A] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6000978	chr1	639	22		661	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of GADD45A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GADD45A expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of GADD45A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GADD45A expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of GADD45A expression and immune infiltrating cell level correlation result in HTLV1+ samples
GADD45A expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).