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HTLV1 Target gene Detail Information

> GABRG2 Gene Search Result


Gene Information
Gene Name GABRG2
Gene ID 2566
Gene Full Name gamma-aminobutyric acid type A receptor gamma2 subunit
Gene Alias CAE2; ECA2; GEFSP3
Transcripts ENSG00000113327
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID P18507
HGNC ID HGNC:4087
VEGA ID OTTHUMG00000130350
OMIM ID 137164
String ID 9606.ENSP00000410732
Drugbank ID BE0003592; BE0008668
PharmGKB ID PA28501
Target gene [GABRG2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6031153 chr5 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of GABRG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GABRG2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of GABRG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GABRG2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of GABRG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
GABRG2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).