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HBV Target gene Detail Information

> GAB2 Gene Search Result


Gene Information
Gene Name GAB2
Gene ID 9846
Gene Full Name GRB2 associated binding protein 2
Transcripts ENSG00000033327
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;
HPA Protein Class Info Predicted intracellular proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID Q9UQC2
HGNC ID HGNC:14458
VEGA ID OTTHUMG00000166673
OMIM ID 606203
String ID 9606.ENSP00000354952
PharmGKB ID PA28478
Target gene [GAB2] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29893492 G1764A
BCP
G
C
 View

Target gene [GAB2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1016430 chr11 1 1 View
1404483 chr11 180 180 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of GAB2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
GAB2 expression: Low -> High
Lollipop of GAB2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of GAB2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of GAB2 expression and immune infiltrating cell level correlation result in HBV+ samples
GAB2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).