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HTLV1 Target gene Detail Information

> FTH1 Gene Search Result


Gene Information
Gene Name FTH1
Gene ID 2495
Gene Full Name ferritin heavy chain 1
Gene Alias FHC; FTH; HFE5; PLIF; FTHL6; PIG15
Transcripts ENSG00000167996
Virus HTLV1
Gene Type protein coding
HPA Location Info Microtubules;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID P02794
HGNC ID HGNC:3976
VEGA ID OTTHUMG00000166217
OMIM ID 134770
String ID 9606.ENSP00000273550
Drugbank ID BE0000399
PharmGKB ID PA28392
Target gene [FTH1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6002050 chr11 264 31 295 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of FTH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FTH1 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of FTH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FTH1 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of FTH1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FTH1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).