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HBV Target gene Detail Information

> FST Gene Search Result


Gene Information
Gene Name FST
Gene ID 10468
Gene Full Name follistatin
Gene Alias FS
Transcripts ENSG00000134363
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P19883
HGNC ID HGNC:3971
VEGA ID OTTHUMG00000131183
OMIM ID 136470
String ID 9606.ENSP00000256759
Drugbank ID BE0004526
PharmGKB ID PA28388
Target gene [FST] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 29893492 G1764A
BCP
G
C
 View

Target gene [FST] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003241 chr5 148 5 153 View
1401806 chr5 148 5 153 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of FST expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
FST expression: Low -> High
Lollipop of FST expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of FST expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FST expression and immune infiltrating cell level correlation result in HBV+ samples
FST expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).