HBV Target gene Detail Information

> FRK Gene Search Result

Gene Information

Gene Name	FRK
Gene ID	2444
Gene Full Name	fyn related Src family tyrosine kinase
Gene Alias	GTK; RAK; PTK5
Transcripts	ENSG00000111816
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
HPA Protein Class Info	Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	P42685
HGNC ID	HGNC:3955
VEGA ID	OTTHUMG00000015424
OMIM ID	606573
String ID	9606.ENSP00000476145
Drugbank ID	BE0004742
PharmGKB ID	PA28373

Target gene [FRK] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005778	chr6	47	1		48	View
1006974	chr6	24	6	2	32	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of FRK expression and immune infiltrating cell level correlation result in HBV+ samples
FRK expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).