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HBV Target gene Detail Information

> FLT4 Gene Search Result


Gene Information
Gene Name FLT4
Gene ID 2324
Gene Full Name fms related tyrosine kinase 4
Gene Alias PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3
Transcripts ENSG00000037280
Virus HBV
Gene Type protein coding
HPA Location Info Nuclear speckles;Plasma membrane;Cell Junctions;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Uniport_ID P35916
HGNC ID HGNC:3767
VEGA ID OTTHUMG00000130931
OMIM ID 136352
String ID 9606.ENSP00000261937
Drugbank ID BE0000023
Drug (Cytoscape Annotation) Pazopanib Hydrochloride;Vandetanib;Sunitinib Malate;Sorafenib Tosylate;Axitinib;Lenvatinib Mesylate
PharmGKB ID PA28183
FDA Approved Drug Sunitinib;Axitinib;Regorafenib
Target gene [FLT4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001010 chr5 780 302 73 1155 View
1003761 chr5 110 1 111 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of FLT4 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
FLT4 expression: Low -> High
Lollipop of FLT4 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of FLT4 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FLT4 expression and immune infiltrating cell level correlation result in HBV+ samples
FLT4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).