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HTLV1 Target gene Detail Information

> FLT3 Gene Search Result


Gene Information
Gene Name FLT3
Gene ID 2322
Gene Full Name fms related tyrosine kinase 3
Gene Alias FLK2; STK1; CD135; FLK-2
Transcripts ENSG00000122025
Virus HTLV1
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins, RAS pathway related proteins
Gene Function Suppressor gene & Oncogene
Uniport_ID P36888
HGNC ID HGNC:3765
VEGA ID OTTHUMG00000016646
OMIM ID 136351
String ID 9606.ENSP00000241453
Drugbank ID BE0000147
PharmGKB ID PA28181
FDA Approved Drug Gilteritinib;Midostaurin;Venetoclax
Target gene [FLT3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6004141 chr13 122 5 127 View
6011354 chr13 10 12 5 27 View
6032350 chr13 0 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of FLT3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FLT3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of FLT3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FLT3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of FLT3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FLT3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).