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HBV Target gene Detail Information

> FLT1 Gene Search Result


Gene Information
Gene Name FLT1
Gene ID 2321
Gene Full Name fms related tyrosine kinase 1
Gene Alias FLT; FLT-1; VEGFR1; VEGFR-1
Transcripts ENSG00000102755
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;Actin filaments;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Uniport_ID P17948
HGNC ID HGNC:3763
VEGA ID OTTHUMG00000016648
OMIM ID 165070
String ID 9606.ENSP00000282397
Drugbank ID BE0000029
Drug (Cytoscape Annotation) Pazopanib Hydrochloride;Axitinib;Vandetanib;Sorafenib Tosylate;Sunitinib Malate
PharmGKB ID PA28180
FDA Approved Drug Sunitinib;Axitinib;Regorafenib
Target gene [FLT1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002617 chr13 145 52 38 235 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of FLT1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
FLT1 expression: Low -> High
Lollipop of FLT1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of FLT1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FLT1 expression and immune infiltrating cell level correlation result in HBV+ samples
FLT1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).