HIV Target gene Detail Information

> FLNA Gene Search Result

Gene Information

Gene Name	FLNA
Gene ID	2316
Gene Full Name	filamin A
Gene Alias	FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FGS2; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280
Transcripts	ENSG00000196924
Virus	HIV
Gene Type	protein coding
HPA Location Info	Actin filaments;Cytosol;Plasma membrane;
HPA Protein Class Info	Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Gene Function	Suppressor gene
Uniport_ID	P21333
HGNC ID	HGNC:3754
VEGA ID	OTTHUMG00000022712
OMIM ID	300017
String ID	9606.ENSP00000358866
Drugbank ID	BE0009024; BE0009099
PharmGKB ID	PA28172

Target gene [FLNA] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4011663	chrX	2	2	2	6	View
4013513	chrX	1	1	1	3	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of FLNA expression and immune infiltrating cell level correlation result in HIV+ samples
FLNA expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of FLNA expression and immune infiltrating cell level correlation result in HIV+ samples
FLNA expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).