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HBV Target gene Detail Information

> FGFR2 Gene Search Result


Gene Information
Gene Name FGFR2
Gene ID 2263
Gene Full Name fibroblast growth factor receptor 2
Gene Alias BEK; JWS; BBDS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM
Transcripts ENSG00000066468
Virus HBV
Gene Type protein coding
HPA Location Info Cell Junctions;Nucleoplasm;Vesicles;Predicted to be secreted;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Gene Function Oncogene
Uniport_ID P21802
HGNC ID HGNC:3689
VEGA ID OTTHUMG00000019175
OMIM ID 176943
String ID 9606.ENSP00000410294
Drugbank ID BE0000748
Drug (Cytoscape Annotation) Sunitinib Malate;Axitinib;Pazopanib Hydrochloride;Ibrutinib
PharmGKB ID PA28128
FDA Approved Drug Midostaurin;Ponatinib;Bosutinib;Pemigatinib
Target gene [FGFR2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001961 chr10 246 101 49 396 View
1006120 chr10 3 30 10 43 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FGFR2 expression and immune infiltrating cell level correlation result in HBV+ samples
FGFR2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).