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HBV Target gene Detail Information

> FGFR1 Gene Search Result


Gene Information
Gene Name FGFR1
Gene ID 2260
Gene Full Name fibroblast growth factor receptor 1
Gene Alias CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Transcripts ENSG00000077782
Virus HBV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters
Gene Function Oncogene
Uniport_ID P11362
HGNC ID HGNC:3688
VEGA ID OTTHUMG00000147366
OMIM ID 136350
String ID 9606.ENSP00000393312
Drugbank ID BE0002131
Drug (Cytoscape Annotation) Dasatinib;Axitinib;Vandetanib;Sorafenib Tosylate;Ponatinib Hydrochloride;Pazopanib Hydrochloride;Sunitinib Malate
PharmGKB ID PA28127
FDA Approved Drug Bosutinib;Ponatinib;Midostaurin
Target gene [FGFR1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1000966 chr8 46 686 489 1221 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FGFR1 expression and immune infiltrating cell level correlation result in HBV+ samples
FGFR1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).