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HTLV1 Target gene Detail Information

> FGF2 Gene Search Result


Gene Information
Gene Name FGF2
Gene ID 2247
Gene Full Name fibroblast growth factor 2
Gene Alias BFGF; FGFB; FGF-2; HBGF-2
Transcripts ENSG00000138685
Virus HTLV1
Gene Type protein coding
HPA Location Info Nuclear bodies;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins, Transporters
Uniport_ID P09038
HGNC ID HGNC:3676
VEGA ID OTTHUMG00000039506
OMIM ID 134920
String ID 9606.ENSP00000264498
Drugbank ID BE0001015
PharmGKB ID PA28115
Target gene [FGF2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000302 chr4 1142 622 487 2251 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of FGF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGF2 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of FGF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGF2 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of FGF2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGF2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).