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HTLV1 Target gene Detail Information

> FGD6 Gene Search Result


Gene Information
Gene Name FGD6
Gene ID 55785
Gene Full Name FYVE, RhoGEF and PH domain containing 6
Gene Alias ZFYVE24
Transcripts ENSG00000180263
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q6ZV73
HGNC ID HGNC:21740
VEGA ID OTTHUMG00000170133
OMIM ID 613520
String ID 9606.ENSP00000344446
PharmGKB ID PA134967436
Target gene [FGD6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000766 chr12 826 37 8 871 View
6013889 chr12 16 2 18 View
6024788 chr12 3 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of FGD6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGD6 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of FGD6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGD6 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of FGD6 expression and immune infiltrating cell level correlation result in HTLV1+ samples
FGD6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).