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HBV Target gene Detail Information

> FGB Gene Search Result


Gene Information
Gene Name FGB
Gene ID 2244
Gene Full Name fibrinogen beta chain
Gene Alias HEL-S-78p
Transcripts ENSG00000171564
Virus HBV
Gene Type protein coding
HPA Location Info Endoplasmic reticulum;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P02675
HGNC ID HGNC:3662
VEGA ID OTTHUMG00000150331
OMIM ID 134830
String ID 9606.ENSP00000306099
Drugbank ID BE0002091; BE0009672
PharmGKB ID PA163
Target gene [FGB] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002822 chr4 14 172 16 202 View
1004578 chr4 17 56 4 77 View
1006547 chr4 17 17 3 37 View
1007369 chr4 18 3 7 28 View
1009960 chr4 3 11 14 View
1012456 chr4 3 4 7 View
1013845 chr4 3 1 4 View
1013846 chr4 3 1 4 View
1014262 chr4 4 4 View
1014597 chr4 3 3 View
1016031 chr4 2 2 View
1018941 chr4 0 View
1400149 chr4 2 2 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of FGB expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
FGB expression: Low -> High
Lollipop of FGB expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of FGB expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of FGB expression and immune infiltrating cell level correlation result in HBV+ samples
FGB expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).