HIV Target gene Detail Information

> FBXL12 Gene Search Result

Gene Information

Gene Name	FBXL12
Gene ID	54850
Gene Full Name	F-box and leucine rich repeat protein 12
Gene Alias	Fbl12
Transcripts	ENSG00000127452
Virus	HIV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9NXK8
HGNC ID	HGNC:13611
VEGA ID	OTTHUMG00000180212
OMIM ID	609079
String ID	9606.ENSP00000247977
PharmGKB ID	PA134934043

Target gene [FBXL12] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002263	chr19	86	16		102	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of FBXL12 expression and immune infiltrating cell level correlation result in HIV+ samples
FBXL12 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of FBXL12 expression and immune infiltrating cell level correlation result in HIV+ samples
FBXL12 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).