HPV Target gene Detail Information

> FAT4 Gene Search Result

Gene Information

Gene Name	FAT4
Gene ID	79633
Gene Full Name	FAT atypical cadherin 4
Gene Alias	FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548
Transcripts	ENSG00000196159
Virus	HPV
Gene Type	protein coding
HPA Location Info	Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	Q6V0I7
HGNC ID	HGNC:23109
VEGA ID	OTTHUMG00000133100
OMIM ID	612411
String ID	9606.ENSP00000377862
PharmGKB ID	PA134954366

Target gene [FAT4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5000226	chr4	103	341	94	538	View
5200573	chr4	10	1		11	View
5201063	chr4	10	20	101	131	View
5201763	chr4		1		1	View
5403428	chr4		13		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of FAT4 expression and immune infiltrating cell level correlation result in HPV+ samples
FAT4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662